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The most common side effects are mild to moderate and gone after the treatment is discontinued; the typical adverse reactions are nausea, vomiting, abdominal pain, and diarrhea. Pseudomembranous colitis might occur during or How weeks after the Online. If you experience severe or persistent side effects, speak to your healthcare provider at Antabuse.
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Do not resort to self-treatment as this medication is effective only against certain bacterial infections and does not treat or cure viral infections. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized.
Disulfiram does not appear to influence the rate of alcohol elimination from the body.
Disulfiram is absorbed slowly from the gastrointestinal tract and is eliminated slowly from the body. One or even two weeks after a patient has taken his last dose of disulfiram, ingestion of alcohol may produce unpleasant symptoms.
Indications and Usage for Antabuse Disulfiram Tablets USP are an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied to best advantage. Disulfiram Tablets USP are not a cure for alcoholism. When used alone, without proper motivation and supportive therapy, it is unlikely that it will have any substantive effect on the drinking pattern of the chronic alcoholic.
Contraindications Patients who are receiving or have recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations, e.
The patient must be fully informed of the disulfiram-alcohol reaction. He should be warned to avoid alcohol in disguised forms, i.
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He should also be warned that reactions may occur with alcohol up to 14 days after ingesting disulfiram. The Disulfiram-Alcohol Reaction Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion.
In severe reactions there may be respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death. The intensity of the reaction varies with each individual, but is generally proportional to the amounts of disulfiram and alcohol ingested.
Mild reactions may occur in the sensitive individual Get the blood alcohol concentration is increased to as little as 5 to 10 mg per 100 Antabuse. Symptoms are fully developed at 50 mg per 100 mL, and unconsciousness usually results when the blood 500 level reaches 125 to 150 mg. The duration of the reaction varies from 30 to 60 minutes, to several hours in the more severe cases, or as long as there is alcohol in the blood.
Concomitant Conditions Because of the Online of an accidental disulfiram-alcohol reaction, disulfiram should be used with extreme caution in patients with any of the following How Alcoholism may accompany or be followed by dependence on narcotics or sedatives.
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- Psychotic reactions have been noted, attributable in most cases to high dosage, combined toxicity with metronidazole or isoniazid, or to the unmasking of underlying psychoses in patients stressed by the withdrawal of alcohol.
- It is recommended that the physician contact the local Poison Control Center.
- Geriatric Use A determination has not been made whether controlled clinical studies of disulfiram included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects.
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- He should also be warned that reactions may occur with alcohol up to 14 days after ingesting disulfiram.
- Disulfiram does not appear to influence the rate of alcohol elimination from the body.
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